RXR forms heterodimers with RAR and several other nuclear receptors when bound to DNA, suggesting that RXR may function as a scaffold protein to facilitate DNA binding for several types of nuclear receptors , . RA-induced transcriptional activity is tightly regulated by nuclear co-repressors and nuclear receptor co-activators . RA signaling has also been implicated in early heart patterning, forelimb induction, pancreas induction, lung induction, eye formation, and some aspects of genitourinary tract development , , . However, our current understanding of the role of RA in adult stem cells, and tissue-specific progenitors is relatively limited.
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Lastly, we examined the ability of retinoic acids to potentiate BMP9-induced matrix mineralization. 3D, 9CRA and ATRA were able to augment BMP9-induced mineralization as judged by Alizarin Red S staining. Taken together, the above results strongly suggest that retinoic acids may effectively enhance both early and late stages of BMP9-induced osteogenic differentiation of MPCs.
With the game end-to-end, Emery’s team broke Brighton’s resistance from the penalty spot. Running onto Kamara’s throughball, McGinn got a touch on it before being taken down by Dunk. Taking it off of Digne, Ings took responsibility for the spot-kick, shooting down the middle of the goal.